Coronavirus Pandemic Panic

Too Much Fear—Too Little Faith in the body’s Immune System

The world has been inundated by images and negative data that have created a panic that is perhaps worse than the threat of the Coronavirus itself. The contagion of fear is spreading faster than the contagion of the virus. This is a case of too much negative data and not enough common sense. The positive data has been almost entirely overlooked as the media, pharmaceutical, monetary and industrial complex are focused on the negative. The stress, fear and worry is making matters worse by suppressing immune function.

The Coronavirus is a novel new virus that is now a pandemic and spreading across the globe in more than 198 Countries. Some people are dying, but the hyper-media non-stop focus on the negative exponential spread of this virus and the worst case scenarios, is counterproductive. We are not helpless. We should focus on the positive and have faith in the body’s Innate Cellular Immunity. We can take charge of our own destiny and focus on boosting our own immune systems rather than merely waiting helplessly for a vaccine that will take 12-18 months at best and may not work very well at all, or worse, may cause significant unanticipated harm. 

Highly Contagious but Mostly Mild

For 96% of the world population, SARS-CoV-2 is causing nothing more than mild cold-like symptoms. Some are not experiencing any symptoms at all. Others will have mild to moderate flu-like symptoms and only 2-4% will suffer more serious complications and 1-2% may die due to immune compromise by age or other illnesses, including heart disease, diabetes, or respiratory and auto-immune diseases. Although the total number of cases is rising exponentially, the most telling number is that 98% all of Active Cases in the US are Mild.

Coronavirus Dr Hansen

 Worldwide Stats as of Sunday 3/21/2020 

Ten Times More Asymptomatic Cases than Confirmed Cases

A new report based on data from China finds that for every known case of infection, there could be up to 10 people with the virus who have such a mild case that they have no symptoms and who remain unidentified in the community. This means that the actual number of Coronavirus Cases around the world is probably 10 times higher. This is good news, because this means that this virus is even milder than previously known and the case fatality rate is 10 times less than previously known.

 “Probably hundreds of thousands of people have already had Covid-19, didn’t know they had it, and recovered. Should be tested for antibodies so they could go back to work and keep the economy going.” New York Governor, Andrew Cuomo.

2019-20 Influenza Virus vs COVID-19

Comparison between outcomes for the flu and COVID-19

How to Reduce the Case Fatality Rate by 82%

The immediate and best solution to reduce the risk of serious complications and deaths associated the Coronavirus Pandemic is to focus on the positive rather than isolate in fear.  We all have the inborn ability to fight off viruses and otherwise deadly pathogens, including SARS-CoV-2. Each of us can boost our own Immune System. In fact, we have two Immune Systems: the Humoral Immune System that makes anti-bodies to attack viruses indirectly and the Cellular Immune System that is made up of specialized cells that can be multiplied to attack and destroy viruses directly. This is the Immune System you can affect immediately.

You do not have to live in fear waiting for the discovery of a new drug or vaccine to fight the Coronavirus, you can immediately take a 2-day therapeutic high dose of water-soluble Vitamin A to boost your own Cellular Immune System to find, attack and destroy the virus. 

This is not a new or merely theoretical protocol. This is a therapy that has been used for years in millions of infants and children to reduce the risk of dying from viruses. This protocol recommends taking 200,000 IU of water-soluble Vitamin A daily for two consecutive days. This has been shown to be associated with an 82% reduction in the risk of death from the measles virus in children under the age of two years (RR 0.18; 95% CI 0.03 to 0.61) and this same water-soluble Vitamin A dose has been shown to cause a 77% reduction in the risk of pneumonia specific mortality (RR=0.23; 95% CI 0.02 to 1.05). It should provide the same benefit for adults and similarly boost immune enhancement and protection for all viruses that affect the upper respiratory tract, including coronavirus (SARS-CoV-2).

SourceVitamin A for treating measles in children. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD001479. American Academy of Pediatrics

“Vitamin A is not virus specific to a single virus. It should provide the same or similar benefits for all similar viruses, including the coronavirus.”
– Dr. Clark Hansen N.M.D.

What is Humoral Immunity?

Humoral immunity is antibody-mediated immunity. This part of the Immune System produces antibodies by the B-cells. The first time someone is exposed to a foreign substance, like a virus, it may take the immune system up to two weeks to make an antibody blueprint and to produce enough of a specific antibody to fight the virus. The B-cells need time to make enough antibodies to bind to the invading viruses indirectly and prevent them from spreading throughout the body. However, if the individual has a robust Cellular Immune System, these Specialized Immune Cells, including T-Helper Cells, Cytotoxic T-Cells, Monocytes and Macrophages, can bind to the viruses and destroy them directly. (See: British Society of Immunology: Immune responses to viruses)

Coronavirus Dr Hansen

What is Cellular Immunity?

The Cellular Immune System is composed of several different types of Cells that can attack viruses directly. These cells are the keys to hosting an immune response against viruses. T-Helper Cells play a major role in defense against viruses, protozoa and intracellular bacteria. They help activate Cytotoxic T-Cells and Macrophages to attack infected cells, and they are needed to stimulate B-Cells to secrete antibodies. (For more information, see: Cells of the Immune System)

Coronavirus Dr Hansen

Cytotoxic T-Cells and Natural Killer (NK) Cells 

When a virus infects someone, it is looking for a host in which to live and multiply. It first invades the epithelium (lining) and mucous membranes of the nose, mouth, lungs and gastro-intestinal tract. Once inside the host, viruses replicate and begin to spread and virtually cannibalize the host. T-Cells, including Cytotoxic T-Cells from the Cellular Immune System circulate throughout the body looking for infected cells in the body where Viruses hide. 

Cytotoxic T-Cells carry specialized proteins on their surface that help them to find and recognize virus infected cells. These proteins are called T-Cell receptors (TCRs). In order to find Viruses that are hiding inside the host cells, Cytotoxic T-Cells use molecules called class I major histocompatibility complex proteins (MHC class I) to display pieces of protein from inside the cell upon the cell surface. Cytotoxic T-Cell can then see viruses hiding inside the cells and release cytotoxic chemicals that break the cells apart and kill the invading viruses hiding inside.

Natural Killer Cells, known as NK Cells for short, are specialized type of T-Cells that kill cells that are hard to find because they have a reduced number of MHC class I molecules on their cell surfaces.  When the NK Cell finds a cell displaying fewer than normal MHC molecules it releases a burst of toxic substances, in a similar way to Cytotoxic T-Cells, which kills the virus-infected cell.

Monocytes, Macrophages and Inflammation

Monocytes and Macrophages are two additional critically important cells of the Cellular Immune System. Monocytes and Macrophages are key regulators of inflammation, tissue repair and regeneration involved in a viral infection. Following a viral infection monocytes and macrophages undergo marked changes so that they can play critical roles during the initiation, maintenance, and resolution phases of tissue repair. Deficiencies in monocyte and macrophage numbers or function can lead to uncontrolled inflammation, deficient generation of anti-inflammatory macrophages, or failed communication between macrophages and epithelial cells, endothelial cells, fibroblasts, and stem cells or tissue progenitor cells, all contributing to a state of persistent injury, which can lead to the Severe Acute Respiratory Syndrome (SARS) associated with this strain of the Coronavirus, known as SARS-CoV-2.

Coronavirus Dr Hansen

Mechanisms driving major macrophage activation phenotypes in tissue repair, regeneration, and fibrosis

Vitamin A is the Key to Boosting Your Cellular Immunity and Stopping Viruses

Vitamin A Boosts Barrier Defenses

The epithelium lines all outer surfaces and most inner surfaces of the body. It functions as the front-line of defense against the invasion of viruses and other pathogens. Vitamin A is essential for the maintenance of normal protective epithelial tissues throughout the body, including the lining of the lungs and the intestines. This is the first barrier of defense in preventing viruses from penetrating into the body. 

Vitamin A Protects the Epithelium and Mucous Membranes 

Vitamin A promotes mucin secretion in the epithelium, which provides a physical barrier and slows viruses down so that the Cellular Immune System can find and kill them.  Vitamin A deficiency leads to epithelial keratinization, or drying of the epithelial lining and a significantly depressed immune function. When Vitamin A is deficient it reduces the resistance of the lung tissues to invading viruses and it is no longer able to exert its mechanical barrier function, which can lead to respiratory tract infections, severe inflammation and pneumonia.

Vitamin A Boosts Thymus & Cell Mediated Immunity

Vitamin A also plays essential roles in the regulation, differentiation, maturity, and immunological function of all of crucial anti-viral cells of the Innate Cellular Immune System, including the Thymus. Vitamin A supports the Thymus, while deficiency is known cause atrophy of the Thymus.  Innate immune cells are comprised of Macrophages and Neutrophils, which initiate immediate responses to pathogen invasion through phagocytosis (virus digestion) and activation of Cytotoxic T-Cells and Natural Killer T-Cells, which kill viruses by the release of cytotoxic chemicals. 

Vitamin A Boosts Antibody Production

Antibodies represent a specific class of immunoglobulins. Vitamin A can boost the serum levels of Immunoglobulins and thereby enhance antibody production. Vitamin A deficiency leads to a defect in Antibody-dependent immune responses.

Vitamin A is a Powerful Regulator of Inflammation

Vitamin A is also essential for the regulation of tissue inflammation and tissue repair that occurs during a viral infection. Vitamin A promotes the development and differentiation of Monocytes and Macrophages in the lungs and the intestines. Macrophages include M1 Macrophages that secrete proinflammatory cytokines and M2 Macrophages that produce anti-inflammatory factors. (See Figure 1 above)

References:
Role of Vitamin A in the Immune System: J Clin Med. 2018 Sep; 7(9): 258; 

Retinoic Acid as a Modulator of T-Cell Immunity: Nutrients. 2016 Jun; 8(6): 349;

Malnutrition and Infection: Complex Mechanisms and Global Impact: PLoS Med. 2007 May; 4(5): e115. Published online 2007 May 1. doi: 10.1371/journal.pmed.0040115

How to Boost Your Immune System

The most effective treatment for preventing the most serious consequences of the Coronavirus is a 2-day therapeutic megadose of Vitamin A. This is dose of Vitamin A has been recommended and used by the World Health Organization for years to treat millions of children worldwide. It has reduced the death rate from viral pneumonia caused by Measles by 77% in the most seriously ill hospitalized infants and children. SARS-CoV-2 is causing a similar acute respiratory syndrome. Vitamin A can be taken safely to boost your immune system to reduce your risk as well.

Taking 200,000 IU of Vitamin A daily for two consecutive days has been shown to be associated with a 82% reduction in the risk of death from the measles virus in children under the age of two years (RR 0.18; 95% CI 0.03 to 0.61) and a 77% reduction in the risk of pneumonia specific mortality (RR=0.23; 95% CI 0.02 to 1.05). It should provide the same benefit for adults and similarly boost immune enhancement and protection for all viruses that affect the upper respiratory tract, including coronavirus (COVID-19).

Clinical Studies on patients taking Vitamin A for viral pneumonia have shown the patients taking the 2-day Theraeputic dose of  Vitamin A have much shorter hospital stay by almost five compared to the placebo group (WMD -4.72, 95% CI -7.22 to 2.21). Additional research found that the group taking the 2-day Therapeutic dose of  Vitamin A was found to be 5 times more likely to have a complete recovery than the placebo group. (RR 1.54, 95% CI (1.04 to 1.88).

SourceVitamin A for treating measles in children. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD001479. American Academy of Pediatrics

Vitamin A comes in a maximum dose of 25,000iu per capsule, which should be administered in the following dose by age for 2 days:

  • Infants aged <6 months: 50,000iu total per day (1-25,000iu capsule twice daily for 2 days only)
  • Infants ages 6–11 months: 100,000iu total per day (2-25,000iu capsules twice daily for 2 days only)
  • Children aged ≥12 months 200,000iu total per day (4-25,000iu capsules twice daily for 2 days only)
  • Adults: 200,000iu total per day (4-25,000iu capsules twice daily for 2 days only)
  • Pregnant women should NOT take more than 2,500 IU of Vitamin A per day

An additional (third) age-specific dose of vitamin A should be given 2–4 weeks later to children with clinical signs and symptoms of vitamin A deficiency. (Source: CDC, updated 12/13/13)

The above Vitamin A dosing should be taken every 4 weeks during the Coronavirus Outbreak.

If you get COVID-19 symptoms:

  • Infants and Children should ReSTART the above Regimen
  • Adults should ReSTART 200,000iu total per day for 4 days (4-25,000iu capsules twice daily for 4 days) 

How Much Vitamin A is Too Much? Can it be Toxic?

The acute toxic dose of vitamin A is 25,000 IU/kg (approx. 1.5 Million IU/125 lbs or 2.0 Million IU/175 lbs body weight), and the chronic toxic dose is 4000 IU/kg (200,000 – 315,000 IU) every day for 6-15 months.

Additional Natural Anti-Viral Agents: 

Zinc is Essential for activation of Vitamin A 

Zinc is essential to the activation of Vitamin A and therefore the Cellular Immune System. Zinc is a component of retinol-binding protein, a protein necessary for transporting Vitamin A in the blood. Zinc is also required for the enzyme that converts Vitamin A (Retinol) into Retinal and Retinoic Acid the most active form of Vitamin A.

Zinc is essential for membrane integrity, DNA synthesis and cell proliferation, and thus is needed for all highly proliferating cells, especially the immune cells.  Zinc has been shown to play an important role in regulation of the immune response, particularly T cell-mediated function. Similar to changes observed in the elderly immune response, zinc deficiency is associated with thymus involution, and reductions in lymphocyte proliferation and antibody response

Low zinc status in the elderly contributes to age-associated dysregulation of the immune response and zinc supplementation has been shown to improve Cell mediated Immunity and T-cell function in elderly. Thus, zinc deficiency was indicated as a risk factor for immune deficiency and susceptibility to infection in the elderly. Zinc supplementation may therefore play an important role in the prevention of infectious diseases in the elderly. 

Zinc Dose: 

  • Birth to 2 years: not needed
  • Children 2-12 years of age: 10mg daily 
  • Teenagers: 13-19 years of age: 15mg daily 
  • Adults age 20 and older: 20mg daily

Elderberry, Echinacea and Andrographis

Dr. Hansen Recommends PhytoBiotic. This Anti-Viral Herbal formula contains Elderberry, Echinacea, and Andrographis. Elderberry has been found to be effective against multiple strains of viruses. Elderberry is a neuraminidase inhibitor, like the prescription drug Tamiflu (Oseltamivir). It works by blocking the release and spread of the virus within the body. To be effective it must be taken within 48 hours of the onset of the virus.  Dr. Hansen recommends that this herb be taken for prevention throughout the cold and flu season for all of his patients. 

Directions:

  • Adults: Take 2 PhytoBiotic capsules (200 mg) twice daily as prevention. For active symptoms of all viruses, colds, flus, coughs or sore throats, take 3 Capsules 3 times daily as soon as symptoms arise.
  • Children 6-24 months:give Elderberry (alcohol free) with Vitamin C, from Eclectic Institute, 1ml once daily for prevention, 1ml 4 times daily for active symptoms of the flu beginning as soon as symptoms arise.
  • Children 2-8 yrs old: give Elderberry (alcohol free) with Vitamin C, from Eclectic Institute, 2ml once daily for prevention, 3ml 4 times daily for active symptoms of the flu beginning as soon as symptoms arise.

Don’t Forget Vitamin D3

Vitamin D3. New research is showing that epidemic influenza, and even some of the viruses that cause the common cold, may be prevented by adequate doses of vitamin D, which stimulate the expression of potent anti-microbial peptides, which directly and rapidly destroy the cell walls of viruses.

Directions:

  • Adults:Take 5000 I.U of Vitamin D3 daily.
  • Adolescents (ages 12-18):Take 2000 I.U of Vitamin D3 daily.
  • Children (age 2-11):Take 1000 I.U of Vitamin D3 daily.
  • Children (6mo-2yrs): Take 500 I.U of Vitamin D3 daily.

Summary

Have faith in your Innate Cellular Immune System. Do not cower in fear and isolation. Stress, fear, and worry are immunosuppressive. Hope is healing, it counters fear and boosts immunity. You can take charge of your own Immunotherapy. It is critically important to share this positive message with everyone you know. 

Although, the Coronavirus is very contagious, only 5% or less of the cases are serious or life threatening. The positive news is that 95% of the COVID-19 Cases in the World and 98% in the US are Mild. The current Case Fatality Rate is 1.5% and may be 10 times lower (0.15%), because the number of asymptomatic/undocumented Cases is now reported to be at least 10 times higher than previously known. For most people, the chief symptoms feel like a mild cold or flu, with congestion, fever, malaise and cough.

Only 5% of COVID-19 cases are serious enough to require hospitalization. The serious cases are concentrated in patients that appear to be immune compromised by advanced age or other known inflammatory diseases, including heart disease, diabetes, COPD, Asthma, or Auto-Immune Diseases, etc. These are the individuals that need Vitamin A most of all. This is the group that should be quarantined, but not forgotten. Tell them the positive good news. They can take a therapeutic 2-day high dose of Vitamin A to boost their Cellular Immune system, which may reduce their risk of dying by as much as 82%.
 

Your best defense against this novel Coronavirus is your own Immune System. By boosting your Cellular Immunity you are dramatically more likely to successfully resist COVID-19, and develop permanent immunity to SARS-CoV-2.

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Dr Hansen, Hansen Clinic of Natural Medicine

About the Author

Dr. Clark H. Hansen is a licensed Naturopathic Medical Doctor (N.M.D.) who has been in private practice in Scottsdale, Arizona, since 1986. He is the President and Medical Director of the Hansen Clinic of Natural Medicine, Aesthetics and Mesotherapy. Dr. Hansen is one of the most well respected Naturopathic Physicians in the country and a Diplomat of the World Society of Anti-Aging Medicine.

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