BOTOX ® Cosmetic is indicated for the temporary improvement in the appearance of moderate to severe glabellar (frown) lines associated with corrugator and/or procerus muscle activity in adult patients aged 65 years or less.
BOTOX ® Cosmetic 10-minute Treatment— A Quick Tour
Announcing the first and only FDA-approved treatment indicated for the temporary improvement in the appearance of moderate to severe glabellar (frown) lines associated with corrugator and/or procerus muscle activity in adult patients aged 65 years or less. 1
- Response within days, results that can last up to 4 months 1,2
- High rates of improvement, assessed by physicians 1,2
- Patients reported high rates of improvement in the appearance of glabellar lines 1,2
How glabellar lines are formed
Glabellar lines are the dynamic wrinkles between the brows caused by the contraction of corrugator and/or procerus muscles.
Movement of corrugator and procerus muscles can cause the skin between the brows to crease. As skin becomes less elastic over time, repeated contraction of these muscles may create visible lines and wrinkles.
BOTOX ® Cosmetic works on the muscles that cause glabellar lines
BOTOX ® Cosmetic is injected directly into the corrugator and procerus muscles, where it enters the nerve endings to block the release of acetylcholine, the chemical that causes muscles to contract. Once the muscles are at rest, skin becomes smoother.
Results you can see…
In a clinical study (N=537) with BOTOX ® Cosmetic (n=405), the majority of patients (82.5%) reported an improvement in glabellar lines after a week. Results were still visible up to 4 months later. 1,2
Unretouched clinical photos taken at maximum frown before BOTOX ® Cosmetic and after treatment with BOTOX ® Cosmetic at Day 10.
Individual results may vary.
Individual results may vary.
Since the procedure is nonsurgical, no recovery time is needed.
Performed in the office, the simple procedure takes about 10 minutes.
1. BOTOX ® Cosmetic [package insert]. Irvine , Calif : Allergan, Inc; 2002.
2. Data on file, Allergan.
- BOTOX ® Cosmetic is supplied in 100-unit vials.
- BOTOX ® Cosmetic should be reconstituted only with nonpreserved normal saline. Other diluents, including lidocaine, should not be used for reconstitution.
Important Safety Information
BOTOX ® Cosmetic is contraindicated in the presence of infection at the proposed injection sites(s) and in individuals with known hypersensitivity to any ingredient in the formulation.
Serious and/or immediate hypersensitivity reactions have been rarely reported. These reactions include anaphylaxis, urticaria, soft tissue edema, and dyspnea. If such a reaction occurs, further BOTOX ® Cosmetic injection should be discontinued and appropriate medical therapy immediately instituted. BOTOX ® Cosmetic should only be diluted with 0.9% nonpreserved sodium chloride. Other diluents, including lidocaine, should not be used for reconstitution.
Patients with neuromuscular disorders may be at increased risk of clinically significant systemic effects including severe dysphagia and respiratory compromise from typical doses of BOTOX ® Cosmetic.
The most common side effects are headache, respiratory infection, flu syndrome, temporary eyelid droop, and nausea.