Fat Burning Hormones Finally Discovered!

by | Jan 19, 2024

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Finally, it appears that researchers have discovered the cause of age associated belly fat: that insidious accumulation of fat in your abdomen, liver and around your internal organs? This belly fat seems to be the curse of turning 50 and sometimes much younger. The cause seems to be an age associated decline in two key natural hormones that regulate sugar and insulin metabolism.

Doctors have discovered that Ozempic (Semaglutide) and other GLP-1 Peptides, created for Type 2 Diabetes, not only lower blood sugar but raise insulin and boost fat burning that leads to 20%+ weight loss in their patients. Now tons of people without Type 2 Diabetes are asking for Ozempic or other GLP-1 Peptides to help them lose weight.

I have been hearing about Ozempic (Semaglutide) and other GLP-1 Peptides for several months now. I was cautious of course because it is a Big Pharma Drug developed for Type 2 Diabetes, that is only effective if given by a once per week subcutaneous injection and is very expensive. It typically costs more than $1500 per month for the brand name drug. I had also heard it causes nausea and diarrhea and may cause the loss of both fat and muscle.

I had so many people asking me about it that I finally I decided I had to make time to research it on my own. I was surprisingly impressed. I learned that it had amazing scientific support behind it. I was particularly intrigued because it is a copy of two natural hormones made by the body to regulate sugar and insulin, which also increase Adiponectin, another natural fat burning hormone made by fat cells. A deficiency of these hormones appears to be the cause of abdominal fat accumulation. The side effects appear to be caused by giving too high of a dose too quickly, not the Peptide. It appears that too high of a dose causes the nausea and diarrhea and appetite suppression to the point that many people almost completely stop eating. This can be prevented by simply increasing the dose more slowly and incrementally and by implementing some healthy diet changes.

OVERVIEW: Semaglutide (Ozempic) was the first GLP-1 success. Now there is Tirzepatide (Mounjaro), which I believe is an even better choice than Semaglutide (Ozempic) for Weight Loss and Type 2 Diabetes. Tirzepatide (Mounjaro) is a prescription medication that is a copy of two natural hormones: GLP-1 (Glucagon-like peptide-1) and GIP (Glucose-dependent Insulinotropic Polypeptide). It Is the only dual GLP-1 and GIP receptor activating peptide available on the market. It is similar to Semaglutide (Ozempic) but activates both GLP-1 and GIP. It has been shown to cause fewer side-effects than other single GLP-1 Peptides. It can significantly reduce glucose levels and improve insulin sensitivity, as well as reduce body weight by more than 20% and improve fat metabolism in overweight individuals.

COMPOUNDED Tirzepatide + Vitamin B6

I prefer to prescribe the compounded dual fat-burning hormone combination known as Tirzepatide because it is less expensive than the branded Tirzepatide drug Mounjaro and it can be combined with Vitamin B6, which is added as a coenzyme involved in over 150 biochemical reactions in the human body. Vitamin B6 is essential for the healthy metabolism of carbohydrates, lipids, amino acids, and nucleic acids, and participates in optimal cellular signaling. I believe this is the best combination available.

BENEFITS: GLP-1 is a hormone that consists of 30 protein amino acids. It is released by cells found in the intestines. GLP-1 enhances insulin secretion from beta cells found in the pancreas, in response to sugar. It increases insulin expression, prevents beta-cell damage and death, promotes increased insulin from the formation of new beta cells, reduces glucagon secretion, which slows down stomach emptying, decreases appetite, and improves glucose disposal from peripheral tissues.

GIP is an intestinal hormone secreted from enteroendocrine K cells that is released within minutes of eating a meal high in sugar and/or  saturated fats. GIP increases the production and action of insulin to stimulate fat burning. Research indicates that disturbed GIP signaling is present in obesity as well as in diabetes which is associated with the impairment of fat metabolism and fat accumulation in the abdomen, liver and around other internal organs.

Vitamin B6 is associated with optimal metabolism of glucose and the prevention of diabetes, heart disease and cancer. It has antioxidant and anti-inflammatory functions and may lower Advanced Glycation End products (AGEs).

WEIGHT LOSS: Tirzepatide has been shown to increase another intestinal peptide known as Adiponectin. An especially unique benefit of Tirzepatide is its ability to decrease fat cell volume in the abdomen and around internal organs by activating GIP receptors in fat cells. This reduces fat cell production and increases energy expenditure and fat burning. Consistent Tirzepatide administration has been shown to promote weight loss in overweight patients, leading to more than 20% weight loss in over half of the patients.

The STUDY listed below, in the Journal Diabetes, clearly demonstrates that Tirzepatide definitely stimulates fat loss, including 10% of Liver Fat, 2.26 Liters of Visceral Fat, 2.81 Liters of Abdominal Fat, in addition to 30lbs Total Body Weight Loss over a period of 52 weeks.

BLOOD SUGAR CONTROL: Tirzepatide has been shown to provide superior results compared to other Peptides including Semaglutide (Ozempic) in terms of glucose regulation and fat loss in obesity. Researchers have found that Tirzepatide was more effective than Semaglutide at reducing Hemoglobin A1c, which measures the three month average of blood glucose level inside the Red Blood Cells and in stimulating weight loss in Type 2 Diabetes.

INFLAMMATION REDUCTION: By activating GLP-1 receptors, Tirzepatide also decreases excessive inflammatory reactions that are associated with cardiovascular hardening of the arteries. GLP-1 signaling can decrease inflammatory cytokines and NF-kB signaling as well as Matrix MetaloProteinase-9 (MMP-9) activity. MMP-9 has been found to be associated with the pathology of cancers, including cancer invasion, angiogenesis and metastasis.

CARDIOVASCULAR BENEFITS: Additionaly, Tirzepatide has been shown to reduce Glucose, Hemoglobin A1C, Belly Fat, High Blood Pressure and Total Cholesterol, while raising healthy HDL Cholesterol, which are all essential hallmarks of Cardiovascular fitness.

SUMMARY

I believe that Tirzepatide is an amazing next-generation copy of the all-natural hormones that our bodies need to balance blood sugar, insulin, cholesterol and energy. This medication appears to be so close to the natural hormones that it is a good solution to use to reset the body’s healthy balance of Glucose, Insulin and Cholesterol. I believe that it is safe to use for 6-12 months to achieve this goal. Once the balance is restored you should be able to maintain it by adding healthier, more optimal dietary, exercise and lifestyle choices. Adult Onset Diabetes and Heart Disease are now so common in the United States that they are consiered a normal part of aging. It should not be that way. A balanced Tirzepatide+Vitamin B6 Weight Loss Program can help you achieve these goals.

Here is a list of key foods or supplements and activities that you can take to restore and activate your fat regulating hormones:

Mon-unsaturated fats, including Avocado and Olive Oil

Fish/Omega-3 Oil: Daily intake of fish or omega-3 supplementation increased adiponectin levels by 14-60%

High Fiber Diet: increases adiponectin levels by 60-115%

Low Calorie Diet plus exercise increased adiponectin levels in the range of 18-48%.

Cardio Exercise: 3 cardio workouts can increase adiponectin levels up to 260% and stay for elevated to up to 10 weeks.

Grape Seed Extract can raise Adiponectin by 42%

Curcumin (from Tumeric) can raise Adiponectin by as much as 77%

THE BOTTOM LINE

Nature and the body’s internal biochemistry have been designed by God to optimize a fit and trim body and provide dynamic energy for optimal performance. However, today’s modern living promotes a sedentary lifestyle and a high fat, high carb, high sugar, low fiber diet which accentuates the decline of healthy fat burning hormone levels. We have to work harder in the twenty-first century to get fit and stay healthy. Tirzepatide is a copy of the naturally occurring GLP-1 and GIP peptides that regulate Glucose, Insulin, Cholesterol and Fat burning. This is an amazing discovery. This scientific breakthrough highlights the fact that nature has given us hormones that are designed to keep us biochemically balanced, fit and trim.

However, the building blocks needed to make these hormones come from our diet and they are often deficient. It is highly likely that they are being partially blocked by environmental chemicals. Additionally, the activities of daily living that used to promote a fit and trim body are now almost gone, including walking to visit friends and family, or to go to the market, or downtown, or working out doors, farming, hunting, gardening, etc. The good news is that you can restore the balance. I recommend starting with a comprehensive metabolic /hormone blood test and % Body Fat analysis. From here we can create an individualized Weight Loss Program that includes supplementing these newly discovered hormone Peptides in conjunction with the key Diet, Exercise and Lifestyle changes you need to get fit and stay vibrant and healthy for life.

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Hansen Clinic Tirzepatide+Vitamin B6 Weight Loss Program

Dr. Hansen is looking for 20-25 patients who would like to start this program with him. The Program includes Compounded Tirzepatide + Vitamin B6 subcutaneous injections once per week.

  1. Dr. Hansen will administer the injections just under the skin on your abdomen or he will teach you how to give yourself the injections once per week at home.
  2. The Hansen Clinic will dispense your Tirzepatide+Vitamin B6 dose in Pre-filled Syringes with a 30 Gauge x 1/2 inch needle
  3. The Program starts with an office visit at the Hansen Clinic to review the entire program including the Tirzepatide + B6, Diet, Exercise recommendations and to take your Initial Vitals, Weight, Height, % Body Fat, and draw blood for your Initial Fasting Labs (Glucose, Insulin, Hemoglobin A1c, Triglycerides, Total Cholesterol, HDL, LDL, CRP-HS (inflammation marker).
  4. You will measure your weight every week at home.
  5. You will meet with Dr. Hansen every 2 weeks at the Clinic to review your progress and any symptoms and recheck your Vitals, % Body Fat, Heart Rate, and BP.
  6. The Tirzepatide + B6 dose will be increased gradually every month roughly following the schedule listed below with changes up or down in dose as needed to provide a consistent fat loss without side-effects.
  7. At the 3 month Visit, Dr. Hansen will draw blood again to RETEST your LABS to Assess the Status of your Glucose, Insulin, Cholesterol, and Inflammation levels.
  8. At the 6 month Visit, Dr. Hansen will draw blood again to Test your Final LABS to Assess the Status of your Glucose, Insulin, Cholesterol, and Inflammation levels.
  9. The Cost for this Initial Group of 20-25 patient will be $499 per month per person for the first 3 months. The Regular Cost is $599 per month, per person for each of the first 3 months. This is a 3-12 month program dependding on your weight loss needs/goals and the duration of your treatment. There is an additional cost when the dose exceeds 3.75mg of Tirzepatide + Vitmain B6.
  10. If you have any questions, Please call 480-991-5092.

Program Outline

Office Visits1 Office Visit every 2 weeks to check weight, % Body fat & Vitals
LAB TestingFasting Blood Test will be performed on Week 1, Week 12 and Week 24.
MedicationCost Varies according to the dose which will increase each month.mgmlUnits
The expected max dose at 3 months is 5.0 mg (40 Units)1.250.110
The expected weight loss is 1-2 lbs per week.2.500.220
Please understand that there is no guaranteed weight loss amount.3.750.330
The purpose of this initial Program is to develop the best practices5.00.440
to help each individual achieve his or her heathy weight loss goals.6.250.550
7.50.660
8.750.770
10.00.880

To Schedule for the Program – call 480-991-5092

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RESOURCES

The following Clinical Trial Results were published in the Journal of the American Diabetes Association

Volume 72, Issue Supplement_1

June 2023

758P: CLINICAL THERAPEUTICS—INCRETIN-BASED THERAPIES| JUNE 20 2023

758-P: Changes in Liver and Abdominal Fat in Tirzepatide-Treated Patients Achieving Normoglycemia in the SURPASS-3 MRI Substudy 

Diabetes 2023;72(Supplement_1):758-P

https://doi.org/10.2337/db23-758-P

Tirzepatide (TZP) is a novel, once-weekly GIP/GLP-1 Peptide that significantly reduces body weight, liver fat content (LFC) and volumes of visceral and abdominal subcutaneous adipose tissue (VAT and ASAT), Total Cholesterol, LDL Cholesterol, Triglycerides, and Hemoglobin A1C, while it significantly increases the healthy HDL Cholesterol. See Chart below for Study Findings in a 52 Week Clinical Trial.

Tirzepatide 52 Week Clinical Trial Change: Before to After Levels:

Liver Fat (-10%), Visceral Fat (-2.26 Liters), Abdominal Fat (-2.81 Liters), Weight (-14 kg or 30lb), Hemoglobin A1C, (-2.9%) Triglycerides (-34.8mg/dl), HDL (+12.8mg/dl),LDL -9.8mg/dl), Total Cholesterol (-11.0mg/dl).

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